Savannah Guthrie. (Nathan Congleton / TODAY)

The mother of Savannah Guthrie, co-anchor of NBC's "TODAY" show, has been reported missing in Arizona, officials said Sunday.

Nancy Guthrie, 84, was last seen Saturday night in her home outside Tucson, according to a missing persons flyer. She was reported missing by her family around noon Sunday, Pima County Sheriff Chris Nanos said.

Nanos told reporters that aspects of the scene at the home caused "grave concern."

"This one stood out because of what was described to us at the scene and what we found and located just in looking at the scene," Nanos said.

He did not elaborate on what evidence at the home caused such concern.

Homicide detectives were called out to process the scene, Nanos said. Their involvement is not standard protocol, and foul play cannot be ruled out, he said.

Image: Nancy Guthrie. (Pima County Sheriff's Department)

"There are some things there that are concerning to us, we just don't want to miss anything," Nanos toldNBC affiliate KVOAin Tucson.

The Guthrie family said in a statement: "We can confirm this is a missing persons case, and the family is working closely with local law enforcement."

Nancy Guthrie is described as 5 feet, 5 inches tall, weighing 150 pounds, with brown hair and blue eyes. Her family last saw her at home around 9:30 p.m. to 9:45 p.m. Saturday, Nanos said.

"Miss Guthrie is 84 years old and is not in good physical health," the sheriff said, but noted her family reported no cognitive issues.

Drones, an airplane, a helicopter, volunteers and search-and-rescue dogs loaned from Customs and Border Protection were all scouring the area for Guthrie, Nanos said.

Nanos encouraged anyone who has any information to call the sheriff's department.

In their statement, the Guthrie family expressed gratitude for "the outreach, thoughts and prayers" and also asked for anyone with information to contact authorities.

Savannah Guthrie has frequently discussed her close relationship with her mother over the years.

"She loves us, her family, fiercely, and her selflessness and sacrifice for us, her steadfastness and her unmovable confidence is the reason any of us grew up to do anything," she said ina 2022 tributeto her mother on her 80th birthday.

Mother of 'TODAY' co-anchor Savannah Guthrie reported missing in Arizona

The mother of Savannah Guthrie, co-anchor of NBC's "TODAY" show, has been reported missing in Arizona, officials said Sunday...
Bangladesh's ex-leader Hasina and her UK lawmaker niece sentenced in graft case

DHAKA, Bangladesh (AP) —

Associated Press Solicitor Khan Md. Moinul Ahsan, representing the Anti-Corruption Commission, speaks to the media after a Dhaka special judge's court sentenced former Prime Minister Sheikh Hasina to 10 years in jail, in Dhaka, Bangladesh, Monday, Feb. 2, 2026. (AP Photo/Mahud Hossain Opu) FILE- Bangladesh's Prime Minister Sheikh Hasina speaks during a press conference in Dhaka, Bangladesh, on Jan. 6, 2014. (AP Photo/Rajesh Kumar Singh, File) Policemen escort accused Khurshes Alam into the courtroom following a Dhaka special judge's court verdict that sentenced ousted Prime Minister Sheikh Hasina to 10 years' rigorous imprisonment in two corruption, in Dhaka, Bangladesh, Monday, Feb. 2, 2026.. (AP Photo/Mahud Hossain Opu)

Bangladesh Sheikh Hasina

A court inBangladeshon Monday sentenced formerPrime Minister Sheikh Hasinato 10 years in jail and her nieceTulip Siddiq, who is a British lawmaker, to four years in prison in two cases involving a government township project near the capital.

Judge Mohammed Rabiul Alam of the Special Judge's Court-4 also handed down seven-year prison sentences to another niece, Azmina Siddiq, and a nephew, Radwan Mujib Siddiq.

The country's official corruption watchdog filed the cases alleging that Hasina colluded with government officials to illegally secure six plots in the Purbachal New Town Project, near Dhaka, for herself and her family members despite their ineligibility under government regulations.

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The verdicts came as the interim government, headed by Nobel Peace Prize laureateMuhammad Yunus, prepares for Feb. 12 elections. Hasina's former ruling Awami League party has been banned from taking part.

Both Hasina and Tulip Siddiq weresentenced earlier in similar casesand have denounced the verdict. Siddiq said she obtained no land from the government during her aunt's 15-year rule as she is not a Bangladeshi citizen. But the prosecution said she influenced her aunt to provide her mother and two siblings with land in the project, an allegation she rejected outright.

Hasina was previously convictedin four other casesover corruption in the project as she faced charges of misusing power. In those cases, the court sentenced her to a total of 26 years in prison, while her son,Sajeeb Wazed,and daughter, Saima Wazed, received five years each. Hasina's younger sister, Sheikh Rehana, was sentenced to seven years. All of them are currently abroad. Tulip Siddiq lives in the U.K.

Hasina has been in exile in India since Aug. 5 in 2024 when she was ousted in a student-led mass uprising, ending her 15-year rule. She has beensentenced to deathon charges of crimes against humanity involving the uprising when hundreds of people were killed. She denounced the trial process, terming a special tribunal as "a kangaroo court."

India has not responded to a request from Bangladesh to extradite Hasina.

Bangladesh’s ex-leader Hasina and her UK lawmaker niece sentenced in graft case

DHAKA, Bangladesh (AP) — Bangladesh Sheikh Hasina A court inBangladeshon Monday sentenced formerPrime Min...
Ex-minister Mandelson quits Britain's Labour Party after new Epstein reports

By William Schomberg

Reuters

LONDON, Feb 2 (Reuters) - Former British government minister Peter Mandelson said he had resigned as a member of Prime Minister Keir Starmer's Labour Party after new ​reports of his ties with late U.S. sex offender Jeffrey Epstein.

Mandelson, who was fired by ‌Starmer as Britain's ambassador to the United States last year after previous revelations about his connections to Epstein, said he ‌did not wish to cause "further embarrassment" to Labour.

"I have been further linked this weekend to the understandable furore surrounding Jeffrey Epstein and I feel regretful and sorry about this," Mandelson said in a letter to the Labour Party which was shared with British media.

PLANS TO INVESTIGATE LATEST ALLEGATIONS

Mandelson said he believed that allegations ⁠about financial payments to him by ‌Epstein, which were published by British media based on files released by the U.S. Justice Department, were false and said he would investigate them. The Financial ‍Times said the files showed that accounts connected to Mandelson had received $75,000.

"While doing this I do not wish to cause further embarrassment to the Labour Party and I am therefore stepping down from membership of the party," the ​letter said.

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Olivia Bailey, a minister in Britain's Department for Education, told Times Radio on Monday ‌that it was "right" Mandelson was no longer a member of the Labour Party.

During the late 1990s, Mandelson had an important role in Labour's electoral success as Tony Blair became prime minister.

Mandelson came under scrutiny last year when U.S. lawmakers released documents including a letter in which he called Epstein "my best pal", leading to his dismissal as Britain's envoy in Washington.

Mandelson also had a turbulent earlier career in domestic ⁠politics. In 1998, he quit as trade minister over ​a loan he received from a fellow minister to buy ​a house following questions over conflict of interest.

A second stint in the cabinet also ended in a resignation in 2001 when he was forced out over his alleged ‍involvement in a passport ⁠scandal involving an Indian billionaire. He was later cleared of acting improperly.

Mandelson, a former European Union trade commissioner, is on leave of absence as a member of the upper house of ⁠Britain's national parliament.

Separately, Starmer said on Saturday that Britain's former Prince Andrew should testify before a U.S. congressional committee, ‌following new revelations about his links to Epstein.

(Writing by William Schomberg, additional reporting by Sarah ‌Young and Sam Tabahriti; Editing by Chris Reese)

Ex-minister Mandelson quits Britain's Labour Party after new Epstein reports

By William Schomberg LONDON, Feb 2 (Reuters) - Former British government minister Peter Mandelson said he ha...
Jarrett Allen scores career-high 40 points as the Cavaliers beat the Trail Blazers 130-111

PORTLAND, Ore. (AP) — Jarrett Allen scored a career-high 40 points and grabbed 17 rebounds as the Cleveland Cavaliers handed the Portland Trail Blazers their fifth straight loss with a 130-111 victory Sunday night.

Associated Press Portland Trail Blazers forward Jerami Grant, right, drives to the basket beside Cleveland Cavaliers forward Dean Wade, center, and center Jarrett Allen, right, during the first half of an NBA basketball game, Sunday, Feb. 1, 2026, in Portland, Ore. (AP Photo/Amanda Loman) Portland Trail Blazers center Donovan Clingan (23) and Cleveland Cavaliers center Jarrett Allen (31) grab for a rebound during the first half of an NBA basketball game Sunday, Feb. 1, 2026, in Portland, Ore. (AP Photo/Amanda Loman) Cleveland Cavaliers head coach Kenny Atkinson reacts during the first half of an NBA basketball game against the Portland Trail Blazers, Sunday, Feb. 1, 2026, in Portland, Ore. (AP Photo/Amanda Loman) Portland Trail Blazers forward Jerami Grant, left, drives to the basket as Cleveland Cavaliers forward Dean Wade (32) defends during the first half of an NBA basketball game Sunday, Feb. 1, 2026, in Portland, Ore. (AP Photo/Amanda Loman) Portland Trail Blazers forward Jerami Grant (9) drives to the basket past Cleveland Cavaliers center Thomas Bryant during the first half of an NBA basketball game, Sunday, Feb. 1, 2026, in Portland, Ore. (AP Photo/Amanda Loman)

Cavaliers Trail Blazers Basketball

Sam Merrill added 22 points, including six 3-pointers, and the Cavs rebounded from a loss to the Phoenix Suns on Friday night that snapped a five-game winning streak. Allen also contributed five assists and four blocks.

Caleb Love had 21 points for the Blazers, who struggled without top scorer Deni Avdija. He missed the game with a lower back strain.

Portland trailed by 24 but closed the gap in the final quarter, pulling to 106-96 with 7:32 left. The Cavaliers went up 118-104 on Merrill's 3-pointer with 4:15 remaining, and fans streamed toward the exits.

Before the game, Avdijaearned his first All-Star nodwhen he was selected as a Western Conference reserve. Cleveland star Donovan Mitchell was chosen as a reserve in the Eastern Conference.

With the trade deadline approaching, both teams made deals ahead of the game. The Cavsacquired guards Keon Ellis and Dennis Schroderfrom Sacramento in a three-team swap that sent forward De'Andre Hunter to the Kings. The Chicago Bulls received Dario Saric from Sacramento along with draft picks as part of the deal.

Portland acquired forward Vit Krejci from the Atlanta Hawks in exchange for injured center Duop Reath and a pair of draft picks.

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The Cavaliers jumped out to an early 11-point lead, but Love's 3-pointer pulled Portland to 43-41 with just more than five minutes left in the first half. The Cavs led 57-48 at the break.

Dean Wade hit back-to-back 3s to stretch Cleveland's lead to 66-52 in the third quarter.

Blazers guard Blake Wesley played for first time since October after recovering from foot surgery, entering the game in the opening quarter.

The Cavaliers visit the Los Angeles Clippers on Wednesday night.

The Trail Blazers host Phoenix on Tuesday night.

AP NBA:https://apnews.com/hub/NBA

Jarrett Allen scores career-high 40 points as the Cavaliers beat the Trail Blazers 130-111

PORTLAND, Ore. (AP) — Jarrett Allen scored a career-high 40 points and grabbed 17 rebounds as the Cleveland Cavaliers ha...
Carlos Alcaraz plans a kangaroo tattoo to remember his Australian Open victory

MELBOURNE, Australia (AP) — Carlos Alcaraz thinks he might get a small kangaroo tattooed on one leg.

Associated Press Carlos Alcaraz of Spain kisses the Norman Brookes Challenge Cup the morning after defeating Novak Djokovic of Serbia in the men's singles final at the Australian Open tennis championship, in Melbourne, Australia, Monday, Feb. 2, 2026. (AP Photo/Dita Alangkara) Carlos Alcaraz of Spain smiles as he poses with the Norman Brookes Challenge Cup the morning after defeating Novak Djokovic of Serbia in the men's singles final at the Australian Open tennis championship, in Melbourne, Australia, Monday, Feb. 2, 2026. (AP Photo/Dita Alangkara) Carlos Alcaraz of Spain poses with the Norman Brookes Challenge Cup the morning after defeating Novak Djokovic of Serbia in the men's singles final at the Australian Open tennis championship, in Melbourne, Australia, Monday, Feb. 2, 2026. (AP Photo/Dita Alangkara) Carlos Alcaraz of Spain holds the Norman Brookes Challenge Cup the morning after defeating Novak Djokovic of Serbia in the men's singles final at the Australian Open tennis championship, in Melbourne, Australia, Monday, Feb. 2, 2026. (AP Photo/Dita Alangkara) Carlos Alcaraz of Spain kisses the Norman Brookes Challenge Cup the morning after defeating Novak Djokovic of Serbia in the men's singles final at the Australian Open tennis championship, in Melbourne, Australia, Monday, Feb. 2, 2026. (AP Photo/Dita Alangkara)

Australia Open Tennis

It would be a lasting memento of hiswin over Novak Djokovic in the Australian Open men's finalSunday which made him the youngest male player at 22 to complete acareer Grand Slam.

"I already know it's going to be a kangaroo. I just don't know the place," Alcaraz said. "I'm just thinking about the leg but I don't know which calf, whether it will be the right or left one."

Alcaraz posed for photographers Monday with the ornate Australian Open trophy, looking casually stylish in black, in loafers and no socks. The photo shoot took place at the Royal Exhibition Building among gardens in central Melbourne.

Thewomen's singles winner Elena Rybakinawas photographed with her trophy Saturday on the banks of the Yarra River, which runs through Melbourne.

According to Australian media reports, Alcaraz spent the night after his victory with his family in his hotel suite, ordering pizza, beer and champagne.

In a social media post to fans during the photo shoot, Alcaraz said "I still can't believe that I just made it.

"A dream come true for me, a career Grand Slam. I'm enjoying this amazing moment. I can't forget the support and the love I've received."

After completing a 2-6, 6-2, 6-3, 7-5 overDjokovic, a 10-time Australian Open champion, Alcaraz admitted "I hate to lose."

He explained his mindset at the moment of victory.

"Before the last point ... a lot of things came to my mind, to be honest," Alcaraz said. "I was really nervous, I was shaking almost. So once I saw the ball go out, I was like 'alright, I made it.'

"It was a great feeling, thinking about my family and my team as well."

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Chasing completion

He has now set his sights of winning every major prize in tennis: three Masters 1000 titles that have eluded him, a season-ending championship and a Davis Cup with Spain. He has won six of the nine Masters 1000 crowns but has yet to win the Canadian Open, Shanghai and the Paris Masters.

"I hate to lose, so that's my motivation. Trying to lose as less as I can," Alcaraz said. "Yeah, there are some tournaments that I really wanted to win at least once. A few Masters 1000 I just really wanted to complete all the Masters 1000, trying to win each one at least once.

"Obviously the ATP Finals and the Davis Cup is a goal as well. I really wanted to achieve that for my country, for Spain. I set up some other goals for the season and I will try to be ready for, or to try to get those goals."

Joining the greats

Alcaraz joined Don Budge, Fred Perry, Roy Emerson, Rod Laver, Andre Agassi, Roger Federer, Rafael Nadal and Djokovic as only the ninth man to win all four Grand Slams. He was younger than Budge by 91 days and considerably younger than Nadal who was 24 and three months, Federer almost 28 and Djokovic 29.

"I'm going to say tennis really beautiful but the bad part of tennis is we have tournaments week after week after week and sometimes you don't realize what you've been doing lately," he said. "Because once you finish a tournament, you've got to be prepared and your mind is about going to the next tournament.

"What I've learned this year is to appreciate and enjoy every single second of the moment you're living. Not only lifting the trophies but playing tournaments, playing tennis, getting victories, getting losses. Whatever it is, just enjoy and appreciate the life you're living."

While Alcaraz has acknowledged the 38-year-old Djokovic as an inspiration, he's not sure he will be as durable.

"You know, let's see how long I will be playing. Hopefully being in such a great shape at 38, competing and challenging the young players, and playing finals of grand slams."

AP tennis:https://apnews.com/hub/tennis

Carlos Alcaraz plans a kangaroo tattoo to remember his Australian Open victory

MELBOURNE, Australia (AP) — Carlos Alcaraz thinks he might get a small kangaroo tattooed on one leg. Aust...
For Seahawks, Sam Darnold and Klint Kubiak's last dance together gains greater importance

SAN FRANCISCO — As theSeattle Seahawkspiled out of their charter jet and descended down flights of stairs to the tarmac at San Jose Mineta International Airport, there were few camera phones in the hands of players and even less pomp or vanity in their swagger. It was a little past 5:30 p.m. Standard issue gray sweats were the overwhelming choice of attire. And the mission appeared to be swift: Get off one plane. Get on four busses. Get this show on the road.

Yahoo Sports

Among Super Bowl arrivals, it was a standard issue "business trip."

In the midst of the transit,Seattle quarterback Sam Darnoldwent to one bus. Offensive coordinator Klint Kubiak went to another, joining the team's coaching staff and traveling personnel. Soon enough, the parting of their company will become more permanent, withKubiak expected to reach an agreement to be the head coach of the Las Vegas Raidersshortly after the Super Bowl. For the Seattle faithful, this was the bittersweet note that hung in the air Sunday, whether you were milling about in San Francisco — where the NFL is prepping for a multitude of events surrounding the game — or 40 miles to the south in San Jose, trying to catch a glimpse of the Seahawks' airport touch down.

This Seattle roster and staff is on the doorstep of the ultimate goal, and the band is already headed for a breakup of sorts. This happens, of course. Kubiak and Darnold are certainly not the first coordinator and quarterback tandem to head into a Super Bowl knowing that divergent paths are coming. We've seen it happen four times in the past eight Super Bowls — three times with thePhiladelphia Eagles, with Frank Reich (LII), Shane Steichen (LVII) and Kellen Moore (LIX), and once with theLos Angeles Ramsand Kevin O'Connell (LVI).

Kubiak is expected to make it five in nine after Sunday. And when he departs, it will leave Darnold entering the 2026 season with his eighth —eighth— different offensive coordinator in nine NFL seasons. If ever there were extra motivation to make this Super Bowl appearance count for a franchise, it's the mystery of how Kubiak's departure could ripple for the franchise and its quarterback.

[Get more Seahawks news: Seattle team feed]

Yes, Darnold has certainly done enough to earn the belief that he can maintain his current level of play through another coordinator transition. But it doesn't change the risk that comes with it. The departures of Reich, Steichen and Moore all had an impact on the Eagles' offenses in the ensuing season — and it wasn't positive. And while the Rams' post-Super Bowl offensive crash had as much to do with injuries as losing O'Connell, his departure took a short-term toll on head coach Sean McVay.

And lest we forget, it is Darnold who has pointed to Kubiak several times along this journey as being a factor in his decisions or success. Going all the way back to his signing in free agency, when he related that his level of comfort in signing with Seattle was due to having worked with Kubiak during Darnold's 2023 season with theSan Francisco 49ers. Darnold was a backup for that 49ers team and Kubiak was the passing game coordinator.

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"[Working in a familiar scheme] was definitely one of the things that I factored into signing here," Darnold said in March. "And again, just being able to work with Klint, and having talked a ton with Klint in San Francisco about kind of what we liked, disliked. We have so much in common when it comes to football."

That's not a nothing sentiment. And you don't instantly create it out of thin air with Kubiak's replacement, even if it's from an internal candidate being promoted on the staff. There's still a rhythm that comes with continuity between a quarterback and whoever is calling plays. Darnold alluded to that in June during organized team activities, when he spoke to having to learn new systems along his career and find a fit with each new play-caller.

"I think at the end of the day a lot of teams do similar things but just call it different names," Darnold said this past summer. "That's the part that you've got to learn — learning kind of how Klint calls it and what we're calling it in general, and learning just the terminology and all the things that come with that."

Seattle Seahawks quarterback Sam Darnold, center, speaks as offensive coordinator Klint Kubiak, left, and head coach Mike Macdonald, right, listen during an introductory news conference Thursday, March 13, 2025, at the NFL football team's facilities in Renton, Wash. (AP Photo/Lindsey Wasson)

There's adjustment and fine-tuning. Sometimes it works with an internal hire. Other times, the fit flops. The Eagles have been a stark example following their last two Super Bowl appearances. After Steichen left after the 2022 season, quarterbacks coach Brian Johnson was elevated to the offensive coordinator spot. It proved to be a poor fit and Johnson was fired after one season that saw the Eagles' offense regress. History repeated itself for the Eagles this season, when passing game coordinator Kevin Patullo took over as offensive coordinator following Moore's departure toNew Orleans, only to see the offense again sputter and lead to Patullo's firing after one season.

Along the way, the play ofJalen Hurtshas suffered setbacks. The question for the Seahawk is whether they can avoid a similar fate with Darnold, whose last three offensive play-callers have been Kubiak, O'Connell with theMinnesota Vikingsand then Kyle Shanahan during his stint as a 49ers backup. That's a tough act to follow for whoever slides into Kubiak's seat.

None of this is meant to say Kubiak was perfect. Seattle's offense didn't really hit its stride until late in the season, at least partially because of inconsistency in the run game early on. And Darnold has had to carry the load only intermittently along the way, thanks in large part to Seattle's defense. But he's also been resilient, bouncing back from two regular-season games against the Rams that saw him throw six interceptions, to engineer an NFC title game win last month that was inarguably the best high pressure game of his entire eight-year career.

It was also one of Kubiak's most superbly called games. Balanced with the run early, then gradually opened up into higher risk downfield throws that resulted in pivotal chunk plays, then putting the ball into Darnold's hands late in the fourth quarter — with a pair of must-have first downs off play-action passes — rather than trying to salt away clock by simply running the ball. It's a groove and confidence between quarterback and play-caller that stretches back to the fourth quarter and overtime of Week 16 against the Rams. And it might carry into Sunday against theNew England Patriots.

Now all of that is expected to come to an end, with Kubiak departing and the Seahawks' top priority suddenly being yet another offensive coordinator for Darnold. The bittersweet business trip began on Sunday. Where it takes the Seahawks in 2026 is anyone's guess.

For Seahawks, Sam Darnold and Klint Kubiak's last dance together gains greater importance

SAN FRANCISCO — As theSeattle Seahawkspiled out of their charter jet and descended down flights of stairs to the tarmac ...
Sanofi's genetic disorder drug shows mixed results in late-stage trials

By Bhanvi Satija

Reuters

LONDON, Feb 2 (Reuters) - French drugmaker Sanofi said on Monday that its experimental genetic disorder treatment showed promise in a late-stage study of patients with ​a type of Gaucher disease, but failed to meet the main goal in ‌a separate trial.

The oral drug, venglustat, was being tested in patients with Fabry disease and type 3 Gaucher disease. Both ‌inherited conditions are caused by enzyme deficiencies that lead to the accumulation of toxic substances in the body.

Previous failures in trials of patients with Parkinson's disease and a type of acute kidney disease have prompted Sanofi to prioritize testing the drug in rare genetic disorders, where its mechanism of ⁠blocking the buildup of harmful fatty ‌molecules has yielded promising early-stage results.

Analysts have not projected future sales for venglustat as market expectations for its success remain low.

Sanofi is banking on ‍its late-stage pipeline and recent acquisitions to help drive sales growth in the next decade, after the top-selling eczema and asthma drug Dupixent it shares with Regeneron loses exclusivity.

Sanofi's bet could pay off if venglustat is ​eventually approved, making it the first such drug to target neurological symptoms and giving patients ‌an oral dosing option.

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"A daily pill could make a serious difference for Gaucher patients facing neurological challenges," said Sanofi research chief Houman Ashrafian.

But the drug's path to regulatory approval looks murky, especially for Fabry disease. Ashrafian said data from the Fabry disease study was still being analysed, while the company said it would work with global regulators to determine next steps.

STUDY DETAILS

The drug ⁠showed superior improvements in neurological symptoms such as speech ​and limb coordination for type 3 Gaucher disease patients, ​compared to those who received enzyme replacement therapy. It also demonstrated statistically significant improvements on three of four secondary goals of that study.

In patients with Fabry ‍disease, venglustat helped reduce ⁠neuropathic and abdominal pain, but not enough to declare statistical success. Sanofi suggested that may be due to a large placebo effect. The company said it helped reduce levels ⁠of plasma lyso-GL-3 in patients, which is an indicator of accumulated harmful fat molecules.

Sanofi already sells Fabrazyme, an enzyme‑replacement ‌therapy for Fabry disease, and markets Cerezyme and the oral drug Cerdelga for ‌Gaucher disease.

(Reporting by Bhanvi SatijaEditing by Bill Berkrot)

Sanofi's genetic disorder drug shows mixed results in late-stage trials

By Bhanvi Satija LONDON, Feb 2 (Reuters) - French drugmaker Sanofi said on Monday that its experimental gene...

 

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