Marleen Moise/WireImage; Amy Schumer/Instagram Amy Schumer showed off her dramatic weight loss in an Oct. 4 Instagram post The comedian and actress' slimmer figure could be seen as she posed for a photo with friends Alex Saks and Jillian Bell Schumer has been candid about her weight loss journey, including her experiences with weight loss drugs Ozempic and Mounjaro Amy Schumeris showing off her slimmer figure. The comedian and actress, 44, shared anInstagrampost on Saturday, Oct. 4, featuring a photo of herself on a recent trip to Las Vegas with pals Alex Saks and Jillian Bell. Sporting a Miu Miu button-down mini shirt dress, which she paired with a pair of classy black heels, Schumer's major weight loss could be seen. In the comments section of the post, Schumer's friends complimented her body transformation. "Amy … legs need to come out more!!!" skincare expert Georgia Louise wrote, whileLee Danielssaid, "Skinnnnnnnny mommmmma." AddedReal Housewives of New Jersey'sMargaret Joseph: "Ok legs for days!!🔥🔥❤️." Never miss a story — sign up forPEOPLE's free daily newsletterto stay up-to-date on the best of what PEOPLE has to offer, from celebrity news to compelling human interest stories. Amy Schumer/Instagram Schumer has been open about her weight loss journey in the past, including her "horrible experience" with Ozempic, since she revealed she had liposuction in 2022. "I have this gene, GDF15, which makes you extremely prone to nausea, which is why I was so sick during my pregnancy," she said during a January appearance onHoward Stern's SiriusXM show. "So, I tried Ozempic almost three years ago, and I was, like, bedridden. I was like, vomiting — and then you have no energy. But other people take it, and they're all good. So, God bless them." Adding that she couldn't even throw a ball back and forth with her 6-year-old sonGene David, whom she shares with husbandChris Fischer, Schumer went on to admit that the symptoms that resulted from taking the drug weren't worth therapid weight loss. She also spoke about the drug withAndy CohenonWatch What Happens Livein June 2023, stating, "Everyone has been lying, saying, 'Oh, smaller portions.' Like shut the f--- up. You are on Ozempic or one of those things or you got work done. Just stop." "Be real with the people. When I got lipo, I said I got lipo," Schumer added. More recently, theTrainwreckactress said she's found acombination of medications that yielded good results: estrogen and progesterone for her perimenopause symptoms, and Monjauro, a GLP-1 drug for type 2 diabetes that is also often prescribed for weight loss. Never miss a story — sign up forPEOPLE's free daily newsletterto stay up-to-date on the best of what PEOPLE has to offer, from celebrity news to compelling human interest stories. "My symptoms of being in perimenopause have disappeared. My hair is fuller, my skin is better, I have more energy," Schumer wrote onInstagramin March. "I'm having a really good experience, so I wanted to keep it real with you about that." Schumer previously toldThe Hollywood Reporterthat it's important for her to always be transparent about weight loss and her health. "Everybody on camera is doing this s---, I just wanted to be real about it," she said in an interview with the publication. Read the original article onPeople